Amir Shamshirian

Amir Shamshirian is an immunology and biomedical researcher with experience in T cell biology, graft-versus-host disease (GVHD), and cytokine signalling. He is currently completing his PhD in Immunology at QIMR Berghofer and The University of Queensland, where his research focuses on the role of transcription factors and cytokine regulation in immune responses, particularly in the context of stem cell transplantation.

His work in Associate Professor Kate Gartlan's Immunopathology Laboratory investigates the role of cytokines in GVHD pathogenesis, examining their contrasting effects on tissue damage and epithelial regeneration. A key aspect of his research involves developing and applying intestinal organoid models to study cytokine-mediated epithelial repair and barrier integrity, providing promising insights into potential therapeutic interventions for gastrointestinal GVHD. Additionally, he utilises preclinical murine models of GVHD to investigate the role of transcription factors in immune regulation, disease progression, and therapeutic targeting.

His research integrates advanced molecular biology techniques, flow cytometry, microscopy, and transcriptomic analyses to elucidate immune-modulatory mechanisms and identify novel therapeutic targets.

With expertise spanning clinical, preclinical, and computational research, Amir has been actively involved in biomedical research both during his PhD and in prior roles as a research assistant.

He has contributed to patient recruitment, trial coordination, immune profiling, and meta-analyses across multiple projects, including clinical trials and translational immunology studies. His interdisciplinary approach combines clinical, experimental, and bioinformatics to dissect immune responses, aiming to advance therapeutic strategies for immune-mediated diseases.