About
Dr Graham Radford-Smith is an Honorary Group Leader at QIMR Berghofer. In addition he is also the director of Integrated Gut Health (IGH), a new, holistic model of healthcare for gastroenterology and a Senior Staff Specialist at the Royal Brisbane and Women’s Hospital, with major clinical (Inflammatory Bowel Disease (IBD) Service) and administrative (Pre-eminent senior staff specialist) roles in running of the Gastroenterology Department and the delivery of IBD services to Metro North, Wide Bay and Central Queensland.
Dr Radford-Smith’s major research interests include: inflammatory bowel diseases (Crohn’s disease, ulcerative colitis); the utilisation of health information to optimise patient care and patient outcomes; and, the role of the gut in human disease. Dr Radford-Smith is a passionate advocate for the optimisation of patient outcomes and how we as a healthcare community can best utilise, audit and research to optimise clinical practice.
Working with his team, he has developed an efficient translational model for Gastroenterology research facilitated by the proximity of QIMR Berghofer to the hospital clinics. In addition he has played a lead role in the development and maintenance of bespoke software to help run both clinical and research programmes as interconnecting circuits. Dr Radford-Smith’s scientific expertise crosses several disciplines as evidenced by his publication record of over 179 peer-reviewed full publications to date in the field of gastroenterology.
Dr Radford-Smith is a founding member of the International IBD Genetics Consortium and a senior collaborator with the North American (NIDDK) IBD Genetics Consortium. He is also the past – President of the Gastroenterology Society of Queensland and previous Chair of the Queensland Clinical Scientists Association. He has also served as the chair of the phenotype subcommittee on the International IBD Genetics Consortium and remains a member of the management committee.
Area of Interest
- Role of the microbiome in health and disease Impact of SLC39A8 on the human microbiome
- Development and clinical testing of a colonoscopy triage tool to optimise the triaging of patients into the appropriate prioritisation category (waiting list)
- Development of a simple diagnostic algorithm for high risk Crohn’s disease for primary care physicians
- Development of a new algorithms to determine response to intravenous corticosteroids in subjects presenting with acute severe colitis
Professional Associations
- Gastroenterology Society of Queensland
- Royal Australian College of Physicians
- American Gastroenterology Association
- European Crohn's and Colitis Organisation
Funding
2023 - NHMRC - Novel plant-derived anti-inflammatory drugs for treating IBD
2021 - MRFF - Multicenter (ANZIBD Consortium) PROACTIVE trial for perianal Crohn's Disease (AI)
2020 - QTFF - Provision of a pharmacogenetics testing service using PCR and Sequencing technologies for Queensland patients receiving thiopurine drug therapy (CI)
2019 - Janssen Pharma - Australian Ustekinumab Real-world Observation Research in Crohn's disease (CI)
2018 - RBWH Foundation - Development of a risk assessment tool to improve clinical triage accuracy for colonoscopic investigations (CI)
2015 - NHMRC - A novel nanoparticulate iron supplement and its effect on the gastrointestinal tract (CI)
2015 - NHMRC - Hookworm therapy for celiac disease: a randomised, double-blind, placebo-controlled clinical trial (CI)
2012 - NHMRC - Genomic Medicine: Predictors of Refractory Ulcerative Colitis and Its Response to Treatment (CI)
Publications
Croft A, Okano S, Hartel G, Lord A, Walker G, Tambakis G, et al. A personalised algorithm predicting the risk of intravenous corticosteroid failure in acute ulcerative colitis. Aliment Pharmacol Ther. 2024; 60: 921–933. https://doi.org/10.1111/apt.18190
Marsh, A., Chachay, V., Banks, M. et al. A pilot randomized controlled trial investigating the effects of an anti-inflammatory dietary pattern on disease activity, symptoms and microbiota profile in adults with inflammatory bowel disease. Eur J Clin Nutr (2024).
Lim, Emily, Thai, Maxter, An, Yoon-Kyo, Hendy, Peter, Alchlaihawi, Mahmoud, Leong, Rupert, Connor, Susan, Ng, Watson, Gu, Bonita, Thin, Lena, Sparrow, Miles, Gilmore, Robert, Taylor, Kirstin, Sallis, Olivia, Andrews, Jane M., Daker, Charlotte, Gearry, Richard B., Wark, Gabrielle, Ghaly, Simon, Begun, Matt, Krishnaprasad, Krupa, Wu, Tianhong, Ruddick-Collins, Leonie, Schreiber, Veronika, Okano, Satomi, Radford-Smith, Graham, Schulberg, Julien, van Langenberg, Daniel, Begun, Jakob, High Technical Success Rate of Endoscopic Balloon Dilatation Reduces Surgical Requirement for Patients With Stricturing Crohn’s Disease, GastroHep, 2024, 3686618, 10 pages, 2024. https://doi.org/10.1155/2024/3686618