About
Dr Olga Kondrashova received her PhD on molecular profiling of ovarian cancer from the University of Melbourne in 2016. As part of her PhD project, she was involved in the establishment of the ALLOCATE study, a pilot demonstrating feasibility of genomic profiling patients with recurrent ovarian cancer for allocating patients to targeted therapies.
Following this, Olga commenced postdoctoral studies in Professor Clare Scott’s Laboratory at the Walter and Eliza Hall Institute of Medical Research, on the mechanisms of PARPi sensitivity and resistance in ovarian cancer. In 2019, she joined Dr Nic Waddell’s Group at QIMR Berghofer to further develop her bioinformatic skills and expertise in cancer genomics.
Currently, she is a NHMRC Emerging Leadership Fellow and leads the Molecular Oncology team. Her team focuses on identifying most suitable cancer treatment strategies and treatment biomarkers to enable precision oncology.
Research Skills
- Cancer Genomics
- Molecular Biology
- Bioinformatics
Area of Interest
- Precision oncology
Professional Associations
- 2021-present: member of the Basic and Translational Focus Working Group of EDEN (Endometrial Cancer society – part of ANZGOG)
- 2020-present: member of The Australasian Genomic Technologies Association (AGTA)
- 2021-2023: chair of Postdoctoral Association of QIMR Berghofer (PAQ)
- 2019-2021: member of Postdoctoral Association of QIMR Berghofer (PAQ)
- 2019-2021: co-organiser of QIMR Berghofer Early Career Research Seminar Series
- 2016-present: member of Australian Bioinformatics and Computational Biology Society (ABACBS)
- 2015-present: member of Australian and New Zealand Gynaecological Oncology Group (ANZGOG)
Funding
- NHMRC Investigator Grant “Improving outcomes for patients with homologous recombination deficient cancer” 2022-2026
- NHMRC Synergy Grant “Improving outcomes for lung cancer patients: Discovering targetable vulnerabilities in lung cancer” 2022-2026
- OCRF-ACRF collaborative funding for ovarian cancer research 2024-2026
Research Projects
Current Research Projects
Overcoming PARP inhibitor resistance in ovarian and breast cancer
Predicting pathogenicity of BRCA1 and BRCA2 genetic variants
Overcoming treatment resistance in KRAS-mutant lung cancer
Key Publications
Tran, KA. et al. "Performance of tumour microenvironment deconvolution methods in breast cancer using single-cell simulated bulk mixtures." Nature Communications 14.1 (2023): 5758.
Zeissig, MN. et al. "Next batter up! Targeting cancers with KRAS-G12D mutations." Trends in Cancer (2023).
Bonazzi, VF. et al. "Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer." Genome Medicine 14 (2022): 1-19.