The impact of our research
Cytomegalovirus, or CMV, is a complex and widespread virus that manipulates the immune system to survive.
It can be a dangerous infection for people with weakened immune systems, potentially causing severe disabilities in unborn babies and complications in transplant recipients.
QIMR Berghofer researchers are tackling cytomegalovirus via multiple approaches.
We’ve identified how to deploy one part of an individual’s immune system – or ‘killer T cells’ – to attack the CMV virus, which hides inside cells and can escape detection.
Our scientists have invented a breakthrough vaccine to improve immunity against CMV.
We’ve developed a simple blood test to help doctors monitor an individual’s risk of contracting CMV.
About cytomegalovirus
Cytomegalovirus (CMV) is a common herpes virus that infects people of all ages.
Most healthy people will never develop symptoms, but it can be dangerous for unborn babies and people with compromised immune systems.
CMV is transmitted in body fluids such as saliva, urine, blood, semen, and breast milk.
Around half of Australia's population carries CMV, but most have no symptoms and don’t know they're infected. The virus stays in the body for life and may reactivate at any time.
Pregnant women can pass the virus on to their baby – this is called congenital CMV. Some infected babies will have long-term health problems, such as hearing loss, vision loss, or cerebral palsy.
The virus is also dangerous for transplant patients due to their compromised immune systems.
Healthy people occasionally develop mild symptoms such as fever, sore throat, fatigue, and swollen glands.
Infants, transplant recipients, and those with HIV/AIDS are more likely to have severe complications. CMV can affect internal organs such as the lungs, liver, stomach, and intestines.
Treatment for CMV depends on how severe the symptoms are, as well as the patient’s health.
Antiviral medications may be prescribed for severe cases, especially in immunocompromised patients.
Prevention is crucial, particularly in pregnant women and those with weak immune systems. To reduce your risk of exposure to CMV, it’s best to:
- Practise good hygiene, especially handwashing;
- Avoid close contact with anyone displaying symptoms;
- Practise safe sex;
- Follow proper food safety measures.