Antigen Presentation and Immunoregulation

Dr Kelli MacDonald

Senior Group Leader

Research Focus

The Antigen Presentation and Immunoregulation Laboratory investigates the contribution of donor and host antigen presenting cells (APCs) to immune responses following bone marrow stem cell transplantation.

Basic research in immunology using preclinical models follows three streams: APC development, antigen presentation, and APC induced T cell responses and their regulation.


Research Projects

Current Research Projects

Role of IL-17 and related family members in fibrosis – chronic GVHD and chronic liver disease.

Role of macrophages in GVHD.

Contribution of regulatory T cells to the development of chronic GVHD.


Research Team

Rachael Adams

Timothy Tracey


Funding

  • National Health and Medical Research Council
  • Cancer Council Queensland
  • Leukaemia Foundation Australia
  • The Atlantic Philanthropies
  • Rio Tinto Ride to Conquer Cancer Flagship


Further Information



External Collaborations
  • Professor Geoff Hill, Fred Hutch Cancer Research Center, Seattle
  • Professor Ranjeny Thomas, Diamantina Institute, University of Queensland
  • Professor David Hume, The Roslin Institute, University of Edinburgh
  • Dr Gabrielle Belz, Dr Christine Wells & Dr Jose Villandangos, Walter and Eliza Hall Institute
  • Professor Bruce Blazar, University of Minnesota
  • Dr Andrew Clouston, Envoi Pathology
  • Dr Allison Pettit, UQCCR University of Queensland
  • Dr Justine Mintern, University of Melbourne
  • Dr Patrick Bertolino, Centenary Institute