Background
Virtually all biological processes in eukaryotic cells are regulated by microRNAs that control protein-coding gene expression. Our laboratory has identified a number of different microRNAs that regulate the expression of collagen in liver disease and that can be manipulated to control liver scarring or fibrosis. This project is designed to generate novel, chemically modified microRNAs that can be used as anti-fibrotic therapeutics to treat hepatic fibrosis and thus control the development of cirrhosis and liver cancer in patients with chronic liver disease.
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For Students
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