Background
Acne is a common skin condition that affects individuals worldwide, with significant variation in severity and response to treatment. While environmental factors such as diet, hygiene, and skincare play a role, genetics also contributes substantially to acne risk. Previous genome-wide association studies (GWAS) have identified genetic variants associated with acne, highlighting the involvement of immune function, sebum production, and hormonal pathways. However, further research is needed to understand how genetic risk factors contribute to acne development and severity.
Aim
This project aims to explore the genetic basis of acne by:
- Identifying genetic variants associated with acne risk and severity.
- Investigating whether genetic risk for acne overlaps with other conditions such as depression or metabolic traits.
- Evaluating the predictive power of polygenic risk scores (PRS) for acne.
Approach
The project will utilize data from large genetic studies, including the largest GWAS of acne to date. PRS will be calculated and compared across different acne severity groups. Genetic correlation analyses will assess shared genetic risk factors between acne and other conditions. Statistical analyses will be conducted using software such as PLINK and R.
Project Potential
This project offers the opportunity to gain experience in genetic epidemiology, bioinformatics, and statistical genetics, with potential implications for understanding acne pathophysiology and informing personalized treatment strategies.