Research Focus
The Cancer Genetic Susceptibility Laboratory primarily studies the role of genetics in endometrial cancer risk and development. Our team leads large-scale genetic studies for endometrial cancer and uses these data to answer a variety of research questions falling under three main themes: prevention, prediction and treatment.
Gallery
Research Projects
Current Research Projects
Genome-wide association studies of endometrial cancer
Identification of causal risk factors or modifiable factors for cancer
Endometrial cancer risk prediction model development
Funding
- NHMRC
- US Department of Defense
- Worldwide Cancer Research
- Cancer Australia
- HRC New Zealand
Publications
O’Mara et al, Identification of nine new susceptibility loci for endometrial cancer. NatCommun. 2018. PMID: 30093612 https://pmc.ncbi.nlm.nih.gov/articles/PMC6085317/
Wang et al, Multi-trait genome-wide association study identifies a novel endometrial cancer risk locus that associates with testosterone levels. iScience 2023. PMID: 37168552 https://pmc.ncbi.nlm.nih.gov/articles/PMC10165198/
Wang et al, 10 Years of GWAS discovery in endometrial cancer: Aetiology, function and translation. EBioMedicine, 2022. PMID: 35219087 https://pmc.ncbi.nlm.nih.gov/articles/PMC8881374/
Further Information
- ECAC collaborators (Endometrial Cancer Association Consortium) ecac-studies.org
- BCAC consortium (Breast Cancer Association Consortium) http://apps.ccge.medschl.cam.ac.uk/consortia/bcac/
- Dr Marc Gunter & Dr Laure Dossus, International Agency for Research on Cancer – World Health Organisation
- Professor Emma Crosbie, University of Manchester
- Associate Professor Caroline Ford, University of New South Wales
- Associate Professor Logan Walker, University of Otago
- Associate Professor Jason Gertz, Huntsman Cancer Institute
- Professor Hugo Vankelecom, KU Leuven University
Past Clinical Trials/Studies
- Australian National Endometrial Cancer Study (ANECS)