Research Focus
The Brain Modelling Group mainly focus on neuroimaging data and electrophysiological recordings, and with a little machine learning and network science we tackle problems in psychiatry and neurology. We are also working in the medtech space (both medical device hardware and software), and partnering with clinician collaborators to run a clinical trial. This computational neuroscience work currently follows two major themes: developing new diagnostic methods for neonatal brain health and modelling large-scale brain activity across the lifespan. In neonates, the group uses techniques from physics and machine learning to extract more information than ever before from intensive care monitoring of babies born prematurely. The goal is to enable early detection of injuries and early prognosis of developmental outcomes, so that clinicians can optimise care with personalised markers of brain health, potentially opening the window for new treatments. On the modelling side, the group is harnessing the rapid developments in neuroimaging technology and connectomics to develop new mathematical models of brain activity, in particular at the spatial scales most relevant to human health. The goal is to fill in some of the large gaps in our knowledge of how neuroimaging brain signals emerge from brain structure, on how this relationship varies as we grow and age, and how things can go wrong leading to neurological and psychiatric disorders.
Gallery
Research Projects
Current Research Projects
Modelling large-scale brain dynamics across the lifespan
Novel diagnostics for neurodevelopmental outcomes for at-risk infants and children
Early detection of paediatric sleep disorders via artificial intelligence
Past Research Projects
Modelling COVID-19 in Queensland – Queensland-specific modelling of COVID-19 epidemiology that informed Queensland Government policy on the reopening of borders at the end of 2022.
Research Team
Corey Forrest
Emily Sun
Maple Chen
Funding
- National Health and Medical Research Council
- Margaret Pemberton Foundation
- ARC
Selected publications
L. Webb, A. J. K. Phillips, J. A. Roberts (2024). Mapping the physiological changes in sleep regulation across infancy and young childhood. PLOS Computational Biology 20: e1012541.
K. K. Iyer, J. A. Roberts, M. Waak, S. J. Vogrin, A. Kevat, J. Chawla, L. M. Haataja, L. Lauronen, S. Vanhatalo, N. J. Stevenson (2024). A growth chart of brain function from infancy to adolescence based on EEG. eBioMedicine 102:105061
S. Dutta, K. K. Iyer, S. Vanhatalo, M. Breakspear, J. A. Roberts (2023). Mechanisms underlying pathological cortical bursts during metabolic depletion. Nature Communications 14:4792.
Further Information
- Sampsa Vanhatalo, University of Helsinki
- Michael Breakspear, University of Newcastle
- James Pang, Monash University
- Leonardo Gollo, Monash University
- Melissa Lai, Royal Brisbane and Women’s Hospital
- Roslyn Boyd, University of Queensland
- Paul Colditz, University of Queensland
- Kerstin Pannek, CSIRO
- Susannah Tye, University of Queensland
- Rodrigo Suarez, University of Queensland
- Linda de Vries, University Medical Centre Utrecht, Netherlands
- Gorm Greisen, Copenhagen University Hospital, Denmark
- Katrin Klebermass-Schrehof, Medical University of Vienna, Austria
- John O’Toole, University College Cork, Ireland
- Ana Alarcón Allen, Barcelona Children’s Hospital, Spain
- Michaela Waak, Queensland Children’s Hospital, University of Queensland
- Jasneek Chawla, Queensland Children’s Hospital, University of Queensland
- Ajay Kevat, Queensland Children’s Hospital, University of Queensland
Lab website: https://brain-modelling-group.github.io
Github page: https://github.com/brain-modelling-group